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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
30.3
Human Site:
S12
Identified Species:
44.44
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
S12
R
L
R
S
R
A
L
S
A
F
K
L
R
G
L
Chimpanzee
Pan troglodytes
XP_509931
527
59578
S12
W
L
R
S
R
A
L
S
A
F
K
L
R
G
L
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
S12
R
L
R
S
R
A
L
S
A
F
K
L
R
G
L
Dog
Lupus familis
XP_851216
527
59504
S12
R
L
R
S
R
M
V
S
A
F
K
L
R
G
L
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
S12
R
L
R
S
R
T
V
S
A
F
K
L
R
G
L
Rat
Rattus norvegicus
XP_216727
527
59187
S12
R
L
R
S
R
T
V
S
A
F
K
L
R
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
S18
Y
S
I
S
N
F
C
S
A
I
L
M
T
F
L
Chicken
Gallus gallus
Q5ZKQ6
527
59609
S12
R
L
R
R
R
L
G
S
A
F
R
V
R
G
L
Frog
Xenopus laevis
NP_001083783
527
59670
S12
K
L
K
S
K
V
S
S
A
F
K
M
H
G
L
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
A12
R
V
K
Q
K
V
N
A
G
F
K
M
R
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
N14
P
L
R
K
R
I
T
N
T
F
K
L
C
G
F
Honey Bee
Apis mellifera
XP_001120791
454
52119
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
H21
I
V
K
T
F
Q
I
H
A
F
E
L
K
K
E
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
A12
V
K
T
G
I
S
A
A
F
K
M
N
G
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
R14
A
T
R
R
K
L
Q
R
K
F
R
L
R
G
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
L31
V
L
S
R
K
Y
G
L
S
I
K
S
D
G
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
93.3
100
86.6
N.A.
86.6
86.6
N.A.
26.6
66.6
53.3
40
N.A.
46.6
0
20
0
P-Site Similarity:
100
93.3
100
93.3
N.A.
93.3
93.3
N.A.
33.3
80
80
73.3
N.A.
53.3
0
60
13.3
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
33.3
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
46.6
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
19
7
13
63
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
7
% E
% Phe:
0
0
0
0
7
7
0
0
7
75
0
0
0
7
13
% F
% Gly:
0
0
0
7
0
0
13
0
7
0
0
0
7
75
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% H
% Ile:
7
0
7
0
7
7
7
0
0
13
0
0
0
0
0
% I
% Lys:
7
7
19
7
25
0
0
0
7
7
63
0
7
7
0
% K
% Leu:
0
63
0
0
0
13
19
7
0
0
7
57
0
7
69
% L
% Met:
0
0
0
0
0
7
0
0
0
0
7
19
0
0
0
% M
% Asn:
0
0
0
0
7
0
7
7
0
0
0
7
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
7
7
0
0
0
0
0
0
0
0
% Q
% Arg:
44
0
57
19
50
0
0
7
0
0
13
0
57
0
0
% R
% Ser:
0
7
7
50
0
7
7
57
7
0
0
7
0
0
0
% S
% Thr:
0
7
7
7
0
13
7
0
7
0
0
0
7
0
0
% T
% Val:
13
13
0
0
0
13
19
0
0
0
0
7
0
0
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _